| Pair Name | Embelin, TRAIL | ||
| Phytochemical Name | Embelin (PubChem CID: 3218 ) | ||
| Anticancer drug Name | TRAIL (PubChem CID: / ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Embelin, TRAIL | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->ROS generation | |||
| Gene Regulation | Down-regulation | Expression | MAPK3 | hsa5595 |
| Down-regulation | Expression | SOD1 | hsa6647 | |
| Down-regulation | Expression | XIAP | hsa331 | |
| In Vitro Model | SUM149PT | Breast inflammatory carcinoma | Homo sapiens (Human) | CVCL_3422 |
| Result | Embelin primes IBC cells for TRAIL-mediated apoptosis by its direct action on the anti-caspase activity of XIAP and by shifting the cellular redox balance toward oxidative stress–mediated apoptosis | |||
| No. | Title | Href |
|---|---|---|
| 1 | XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells. Mol Cancer Ther. 2012;11(7):1518-1527. doi:10.1158/1535-7163.MCT-11-0787 | Click |
